Table 1.

Clinical features of neonates born to mothers with perinatal confirmed SARS-CoV-2 infection

	All	Dong et al. [30]	Chen et al. [32]	Li et al. [33]	Wang et al. [34]	Zhu et al. [35]	Chen et al. [36]	Liu et al. [37]	Zeng et al. [38]	Piersigilli et al. (unpublished)
Pregnant women	69	1	9	1	1	9 (1 was a mother of twins)	4	10	33	1
Caesarean section	53/69 (76.8%)	1	9/9	1	1	7/9	3/4	10/10	26/33	1
Positive maternal test (SARS-CoV-2 quantitative RT-PCR on samples from the respiratory tract)	68/69 (98.6%)	1	9/9	1	1	8/9 *	4/4	10/10	33/33	1
Median maternal age, years (range)	30 (22–40)	29	28 (26–40)	30	28	30 (25–35)	29.5 (23–34)	30.5 (22–36)	NA	37
Median gestational age (GA) on admission, weeks (range)	36 (26–39)	38	37 (36–39)	35	30	34 (31–39)	37.5 (37–39)	35.5 (32–38)	NA	26
Median onset of maternal symptoms to delivery, days (range)	2.5 (0–26)	26	3 (1–7)	2	6	2.5 (0–6)	NA	NA	NA	2
Maternal fever on admission	37/69 (53.6%)	1	7/9	1	1	8/10	3/4	8/10	8/33	0
Newborns	70	1	9	1	1	10	4	10	33	1
Positive cord blood samples	0	0 **	0/6	0	0	NA	NA	NA	NA	NA
Positive neonatal throat swab samples	4/63 tested	0 **	0/6	0	0	0/9;1 not tested	0/3; 1 not tested	0/10	3/33	1
Positive breastmilk samples	0	0	0/6	0	0	0/9; 1 not tested	0/3; 1 not tested	0/10	NA	0
Low birthweight (<  2500 g)	14/70 (20%)	0	2/9	NA	1	7/10	0	NA	3/33	1
Premature delivery	24/70 (34.3%)	0	4/9	1	1	6/10	1	6/10	4/33	1
Intrauterine foetal distress	15/69 (22%) + 1 stillbirth	0	0	1	6/10	1/4	3/10 + 1 stillbirth	0	2/33	2/9
Premature rupture of membranes	6/70 (8.6%)	0	2/9	0	0	3/10	0	1/10	3/33	0

NA not available

*The local CDC registered the mother of a couple of twins as a confirmed SARS-CoV-2 because of viral interstitial pneumonia at chest CT scan although RT-PCR returned negative

**In the newborn reported by Dong et al.,they found virus-specific IgG and IgM, high levels of Interleukin 6 and 10, negative nasopharyngeal swab and no symptoms, since two hours from the delivery to the following three weeks