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. 2020 Apr 29;6(18):eaaz6579. doi: 10.1126/sciadv.aaz6579

Fig. 1. Schematic illustration of cellular backpacks for maintaining proinflammatory phenotypes of adoptive MΦ therapies.

Fig. 1

(A) MΦs polarized with IFN-γ ex vivo quickly shift from proinflammatory to anti-inflammatory phenotypes after penetrating a solid tumor. (B) MΦs carrying IFN-γ–loaded backpacks maintain their proinflammatory phenotypes deep within the tumor microenvironment, altering the phenotypes of endogenous TAMs.