Fig. 5. Inhibition of prostate cancer tumor growth by COUP-TFII inhibitor.

CIA1 treatment reduced tumor growth in the mice that bear PC3 xenograft (A), LNCaP-abl xenograft (C), 22Rv1 xenograft (E), and PDX tumor (G). CIA1 (2.6 mg/kg) was given daily by intraperitoneal injection. n = 5 to 6 per group. Two-way ANOVA. The corresponding tumor weight was shown in (B), (D), (F), and (H). n = 5 to 6 per group. t test. *P < 0.05, **P < 0.01, and ***P < 0.001.