Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Molecular structure of Rho‐kinase isoforms. Two isoforms of Rho‐kinase (ROCK1 and ROCK2) consist of three major domains, including a kinase domain on the N‐terminal domain, a coiled‐coil domain with Rho‐binding domain in the centre, and a putative pleckstrin homology (PH) domain with the internal cysteine‐rich domain on the C‐terminal domain. Rho‐kinase activation includes that ROCK1 is specifically cleaved by caspase‐3, whereas ROCK2 is cleaved by granzyme B.
