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Cytokine and epigenetic regulation of RhoA/Rho‐kinase activation. IL‐4, IL‐13, TNF‐α, IL‐17A and CCL2 released from allergen‐activated immune cells regulate RhoA/Rho‐kinase activation through the bindings of their transcriptional factor STAT6 or NF‐kβ to the promoter regions of RhoA gene. MiR‐133a negatively regulates RhoA expression.
