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RhoA/Rho‐kinase signalling controls mesenchymal stem cell lineage commitment in asthma. Increased activation of RhoA/Rho‐kinase signalling induces MSC differentiation into fibroblast/myofibroblasts for allergen‐induced airway remodelling. Decreased activation of RhoA/Rho‐kinase signalling induces MSC differentiation towards epithelial cells for airway repairing. TGF‐β1 from damaged airway epithelial cells plays a major role in MSC migration.
