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. Author manuscript; available in PMC: 2020 Sep 9.
Published in final edited form as: Nat Microbiol. 2020 Mar 9;5(5):715–726. doi: 10.1038/s41564-020-0678-0

Extended Data Fig. 9. All five factors are necessary and sufficient for repair of virion derived rcDNA and a summary of human factors involved in cccDNA formation in this study.

Extended Data Fig. 9

(a) The repair of virion derived type C rcDNA requires all five factors as recombinant rcDNA substrates used in Fig. 4e. (b) The core components involved in DNA lagging strand synthesis – PCNA, RFC, POLδ, FEN-1 and LIG1 – constitute a minimal set of factors for cccDNA formation in this study. All data shown are representatives of two independent experiments.