| Hydroxychloroquine (OHQ): unproven efficacy |
| does not interact with methotrexate or 6-MP |
| be cautious about the use of OHQ with other agents prolonging the QTc interval such as azoles, macrolides, levofloxacin, Tyrosine Kinase Inhibitors ++ |
| Remdesivir: unproven efficacy |
| can be obtained in compassionate use in children (Gilead) |
| described elevation of transaminases. No clear concept on drug interactions (check and update if co-prescription) |
| combination of lopinavir/ritonavir: unproven efficacy |
| may increase the concentration of methotrexate, monitoring is therefore suggested without empirical dose adjustment |
| there is an interaction with vincristine. Dose reduction to be considered |
| no interaction with 6 MP, daunorubicin or pegaspargase |
