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. 2019 Dec 4;33(5):905–915. doi: 10.1038/s41379-019-0418-2

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© The Author(s), under exclusive licence to United States & Canadian Academy of Pathology 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Valid results for both cytoplasmic BUB3 and CCNB1 were obtained for 239 patients. A tumor was considered positive or negative when a tumor was positive or negative for both of the proteins. Heterogeneous scores, where the tumors were positive for either cytoplasmic BUB3 or CCNB1, was observed in 96 patients. Recurrence was defined as locoregional recurrence, metastasis, or death from prostate cancer. The 95% confidence intervals of the hazard ratio (HR) are listed in parentheses.