Table 2.
Multivariable analysis (Cox-regression) of cytoplasmic BUB3 and cyclin B1 (CCNB1) scores combined.
| Variable | HR | 95% CI | p value |
|---|---|---|---|
| Cytoplasmic BUB3 & CCNB1 | <0.001 | ||
| Negative | Ref | ||
| Heterogeneous | 2.55 | 1.44–4.53 | 0.001 |
| Positive | 4.25 | 2.11–8.53 | <0.001 |
| Gleason score | <0.001 | ||
| 3 + 3 | NA | NA | NA |
| 3 + 4 | Ref | ||
| 4 + 3 | 2.88 | 1.10–7.51 | 0.031 |
| ≥8 | 6.49 | 2.57–16.38 | <0.001 |
| Seminal vesicle invasion | 1.52 | 0.91–2.53 | 0.108 |
| Extracapsular extension | 0.87 | 0.32–2.40 | 0.788 |
| Lymph node invasion | 1.99 | 0.90–4.39 | 0.090 |
| Surgical margins | 1.16 | 0.61–2.20 | 0.659 |
| Preoperative PSAa | 0.147b | ||
| ≤6 | Ref | ||
| >6 and ≤10 | 1.19 | 0.39–3.63 | 0.764 |
| >10 and ≤20 | 2.27 | 0.97–5.31 | 0.058 |
| >20 | 2.28 | 0.96–5.38 | 0.061 |
| Agec | 0.96 | 0.92–0.99 | 0.022 |
CI confidence interval, HR Hazard ratio, NA not available
ang/ml
bPreoperative PSA was a significant marker of recurrence when included as a continuous variable in a cox regression model: HR = 1.02, 95% CI 1.00–1.03, p = 0.031
cContinuous variable