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. 2020 Apr 29;10:7273. doi: 10.1038/s41598-020-64131-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intraretinal fluorogold tracing shows the retinal remodeling of the dystrophic strains. (A–E) Magnifications from retinal cross-sections showing fluorogold tracing in young (A) and old (B) SD control rats, and 30 (C), 210 (D) and 400 (E) days old P23H-1 rats. (F–K) Magnifications from retinal cross-sections showing fluorogold tracing in young (F) and old (G) PVG control rats, and 21 (H), 33 (I), 60 (J) and 300 (K) days old RCS rats. In the P23H-1 retinas, aberrations in the retinal layered structure, and the RPE morphology (white arrows in D,E) are observed from P210. The RCS retina degenerates earlier, and at P60 the ONL and the RPE have almost disappeared with only some isolated RPE cells remaining (white arrows in I-K). P: postnatal day. GCL: ganglion cell layer. INL: inner nuclear layer. ONL: outer nuclear layer. RPE: retinal pigment epithelium.