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. 2020 Apr 29;11:2099. doi: 10.1038/s41467-020-15872-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a and b Disrupting malt-1 attenuates Ca²⁺ responses evoked by 21% O₂ in RMG (a) but not URX (b) neurons. The RMG defect can be rescued by expressing malt-1 cDNA in both RMG and URX, using the npr-1 promoter (a). a n = 25 animals (npr-1), n = 35 animals (npr-1; malt-1), n = 24 animals (npr-1; malt-1; npr-1p::malt-1). b n = 20 animals (npr-1), n = 21 animals (npr-1; malt-1), n = 13 animals (npr-1; ilc-17.1). Ca²⁺ responses are reported by YC2.60 cameleon. Lines indicate average speed and shaded regions indicate SEM. n = 20 animals (npr-1), n = 21 animals (npr-1; malt-1), n = 13 animals (npr-1; ilc-17.1). *P = 0.03, ***P = 0.0003, two-sided Mann-Whitney U test. c and d Null mutations in malt-1 and ilc-17.1 do not show additive phenotypes when either RMG Ca²⁺ transients (c) or speed responses evoked by 21% O₂ are measured (d). Lines indicate average speed and shaded regions indicate SEM. c n = 29 animals (npr-1), n = 25 animals (npr-1; malt-1), n = 28 animals (npr-1; ilc-17.1), n = 31 animals (npr-1; malt-1; ilc-17.1). d n = 50 animals (npr-1), n = 61 animals (npr-1; malt-1), n = 67 animals (npr-1; ilc-17.1), n = 52 animals (npr-1; malt-1; ilc-17.1). **P < 0.01, ***P < 0.001, two-sided Mann-Whitney U test. e A transgene expressing malt-1 cDNA from the hsp-16.41 promoter does not rescue malt-1 phenotypes in the absence of heat-shock. Plots show average speed (line) and SEM (shaded regions). n = 35 animals (npr-1), n = 59 animals (npr-1; malt-1), n = 47 animals (npr-1; malt-1; hsp-16.41p::malt-1). P = 0.14, two-sided Mann-Whitney U test. f Heat-shock-induced cDNA expression in adults restores O₂–evoked responses to malt-1 mutants. Plots show average speed (line) and SEM (shaded regions); n = 36 animals (npr-1), n = 48 animals (npr-1; malt-1), n = 33 animals (npr-1; malt-1; hsp-16.41p::malt-1). Plots show average speed (line) and SEM (shaded regions). ***P = 8.77e−06, two-sided Mann-Whitney U test.