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. 2020 Apr 29;11:2094. doi: 10.1038/s41467-020-15783-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cartoon representation of the complex. One MDM2^R is colored green and the other is in magenta. UbcH5B is in cyan and Ub is in yellow. UbcH5B–Ub linkage is indicated. Top and bottom panels are related by 90° rotation about the x-axis. b Surface representation of the complex, colored and oriented as in a (top panel). The N-terminal region preceding the RING domain and the C-terminal tail of MDM2 are indicated. c A cartoon representation of the structure of MDM2-MDMX RING domain heterodimer bound to UbcH5B–Ub (PDB ID: 5MNJ) oriented in the same view as in a (bottom panel). MDM2^R, UbcH5B, and Ub are colored as in a and MDMX RING domain (MDMX^R) is in orange.