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. 2020 Apr 29;10:7288. doi: 10.1038/s41598-020-64211-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of the trajectory plots of $D 1$ for N^f = 226, separated by outcome group. The more deviant trajectories are highlighted by fitting a 95% prediction interval threshold to the normal-outcome data (left plot). The 95% prediction interval is shaded in each plot, with the trajectories highlighted in red when at least one recording exceeded this threshold. The anonymous patient ID is also provided for these cases (in blue). Grey dotted lines show the line for brain-age = PMA.