Table 4.
Quartiles of genetic ancestry by MC1R genetic risk group among subjects with sole Puerto Rican heritage obtained or recruited from the PRBB, CPR, Family Medicine clinics, and the 1000 Genomes Project.
| Quartiles of genetic ancestrya | MC1R risk category | ||
|---|---|---|---|
| Low (N = 131) | Medium (N = 97) | High (N = 69) | |
| N (%) | N (%) | N (%) | |
| European | |||
| <59.9% | 30 (22.9) | 21 (21.7) | 17 (24.6) |
| ≥59.9% and <70.2% | 35 (26.7) | 26 (26.8) | 17 (24.6) |
| ≥70.2% and <78.1% | 35 (26.7) | 32 (33.0) | 11 (15.9) |
| ≥78.1% | 31 (23.7) | 18 (18.6) | 24 (34.8) |
| P-valueb | 0.65 | ||
| P-value(low/medium vs. high)c | 0.47 | ||
| P-value(low vs. medium/high)d | 0.85 | ||
| African | |||
| <9.7% | 35 (26.7) | 20 (20.6) | 19 (27.5) |
| ≥9.7% and <15.4% | 28 (21.4) | 25 (25.8) | 18 (26.1) |
| ≥15.4% and <22.0% | 34 (26.0) | 28 (28.9) | 17 (24.6) |
| ≥22.0% | 34 (26.0) | 24 (24.7) | 15 (21.7) |
| P-valueb | 0.67 | ||
| P-value(low/medium vs. high)c | 0.38 | ||
| P-value(low vs. medium/high)d | 0.97 | ||
| Native American | |||
| <9.0% | 30 (22.9) | 25 (25.8) | 16 (23.2) |
| ≥9.0% and <13.8% | 40 (30.5) | 21 (21.7) | 17 (24.6) |
| ≥13.8% and <19.0% | 36 (27.5) | 29 (29.9) | 14 (20.3) |
| ≥19.0% | 25 (19.1) | 22 (22.7) | 22 (31.9) |
| P-valueb | 0.28 | ||
| P-value(low/medium vs. high)c | 0.31 | ||
| P-value(low vs. medium/high)d | 0.37 | ||
aQuartile cutpoints are based on the distribution of genetic ancestry observed the overall participant sample with successful ancestry genotyping (n = 315).
bP-value is from the Jonckheere-Terpstra test comparing the proportion of participants in MC1R risk categories across quartiles of genetic ancestry.
cP-value is from the Cochran-Armitage test for trend comparing the proportion of participants in a combined low and medium MC1R risk category to that in the high MC1R risk category across quartiles of genetic ancestry.
dP-value is from the Cochran-Armitage test for trend comparing the proportion of participants in the low MC1R risk category to that in a combined medium and high MC1R risk category across quartiles of genetic ancestry.