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. 2020 Apr 29;11:2080. doi: 10.1038/s41467-020-15623-z

Fig. 3. Partial peripheral tissue IR disruption induces an energy defect in the liver of adult mice fed a high-fat diet.

Fig. 3

Ten weeks following high-fat diet (HFD) feeding the livers of male WT and PerIRKO+/− were collected and AMPK activation (phosphorylation), PGC1α expression a, ATP, ADP, AMP levels b, expression of glucose metabolism genes c, and glycogen content d was determined. Results are shown as means ± SE, with n’s represented as individual data point’s in figures. Significance was determined using two-tailed student’s t test; *p < 0.05, **p < 0.01, ***p < 0.001 vs WT.