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. 2020 Apr 29;11:2089. doi: 10.1038/s41467-020-15815-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a Schematic of in vivo E7107 treatment (5 mg/kg/day) in the Hi-Myc PCa model (see Methods). b Weight of the genitourinary (GU) tract (left) or the prostate (right) in Hi-Myc mice treated with vehicle or E7107. P-values were determined by two-tailed unpaired Student’s t-test. c Representative whole-mount Aperio Scanscope images of hematoxylin and eosin-stained prostate sections from two Hi-Myc mice (animal tags indicated) treated with vehicle (top) or E7107, respectively. Solid circled areas mark Hi-Myc tumors in the vehicle group (top), whereas dashed circled regions highlight prominent benign and hyperplastic glands in the E7107-treated group (bottom). d, e Histological analysis of the vehicle (d) and E7107-treated (e) Hi-Myc tumors collected at 46 weeks. Shown are representative HE and MYC, and AR IHC images at low (×4) and high (×40) magnifications. Five tumors were analyzed for each group. Scale bars are also indicated. f Representative images of Ki67 staining in the control (0163 and 0178) and E7107-treated (0188 and 0150) Hi-Myc tumors. Original magnifications, ×40. Scale bar for all panels, 20 μm. Source data are provided as a Source Data file.