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. 2020 Apr 29;10:7277. doi: 10.1038/s41598-020-64305-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Shows that phosphorylated CREB concentration increase in granuloma. This effect was reversible with adding CREB blocker. This figure also shows that expression of IFN-gamma and IL-7 increased in granuloma and significantly reduced after treatment with α-MSH. Granuloma was developed using PBMC of sarcoidosis subjects for this experiment. + and − in the figure show which one is granuloma (+ yes and −no), and treated with α-MSH (+yes, and −no).