Table 4.
Comparison of clinical and pathological characteristics between patients with ALBI grade I and II/III after 1 year of curative resection.
| ALBI grade I (n = 171) | ALBI grade II/III (n = 66) | P value | |
|---|---|---|---|
| Age (years; mean ± SD) | 52.4 ± 10.4 | 56.2 ± 12.3 | 0.019 |
| Age (>60 years), n (%) | 48 (28.1%) | 35 (53.0%) | <0.001 |
| Male, n (%) | 150 (87.7%) | 56 (84.8%) | 0.557 |
| Bilirubin (g/dL; mean ± SD) | 0.8 ± 0.3 | 0.8 ± 0.3 | 0.755 |
| Albumin (g/dL; mean ± SD) | 3.9 ± 0.6 | 3.7 ± 0.5 | 0.038 |
| AFP (>15 ng/mL), n (%) | 94 (55.6%) | 30 (46.9%) | 0.232 |
| Liver cirrhosis, n (%) | 48 (49.1%) | 37 (56.1%) | 0.338 |
| NAs treatment, n (%) | 63 (37.3%) | 21 (32.3%) | 0.635 |
| LAM, n (%) | 8 (12.7%) | 5 (23.8%) | |
| LdT, n (%) | 2 (3.2%) | 1 (4.8%) | |
| ETV, n (%) | 45 (71.4%) | 13 (61.9%) | |
| TDF, n (%) | 8 (12.7%) | 2 (9.5%) | |
| Tumor number (single: multiple) | 9: 162 | 2: 64 | 0.464 |
| Types of surgery | 0.818 | ||
| Right lobectomy, n (%) | 24 (14.2%) | 10 (15.4%) | |
| Left lobectomy, n (%) | 19 (11.2%) | 9 (13.8%) | |
| Segmentectomy, n (%) | 126 (74.6%) | 46 (70.8%) | |
| Child-Pugh grade (A: B) | 163: 8 | 60: 6 | 0.197 |
| MELD score (mean ± SD) | 8.0 ± 2.6 | 7.7 ± 3.2 | 0.496 |
| ALBI grade (I: II) | 80: 89 | 25: 40 | 0.221 |
| Diabetes Mellitus | 27 (15.8%) | 18 (27.3%) | 0.043 |
| Micro/Macrovascular invasion, n (%) | 75 (43.9%) | 32 (48.5%) | 0.521 |
| pTNM stage (I: II: III) | 88: 78: 5 | 31: 27: 8 | 0.021 |
| Histological grade (well: moderate: poor) | 23: 141: 7 | 10: 53: 3 | 0.928 |
AFP = α-fetoprotein, NAs, = nucleot(s)ide analogues, LAM = lamivudine, LdT = telbivudine, ETV = entecavir, TDF = tenofovir, MELD = model for end-stage liver disease, FIB-4 = fibrosis-4, ALBI = albumin-bilirubin.