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. 2020 Apr 29;6:14. doi: 10.1038/s41523-020-0158-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative B-mode ultrasound (top) and sPA (bottom) images of murine mammary glands with either normal (left) or DCIS (right) tissues (red dashed circle) after injection with B7-H3 Ab-ICG. Scale bar = 2 mm. b Box plot of sPA molecular imaging signal (a.u.) distribution in normal mammary glands (n = 17, sPA = 3.2 ± 2.0 a.u.) and DCIS (n = 53, sPA = 22.7 ± 40.2 a.u.). Box plot follows Tukey rules. Glands containing DCIS show statistically significantly higher sPA molecular imaging signal (P < 0.05). c Receiver operating curve depicting the ability of B7-H3 expression imaged by sPA and B7-H3 Ab-ICG to differentiate between normal glands and glands containing DCIS (AUC = 0.93, 95% CI 0.86, 0.99).