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Virus-like particle immunization induces significant cytokine response in goats and sheep. (A–D) Serum was collected 3 weeks after the second immunization from animals immunized with PPRV Tibet/30 VLPs, PPRV Nigeria 75/1 VLPs, or adjuvant and were analyzed for the production of IL-2 (A), IL-4 (B), IL-10 (C), and IFN-γ (D). Data are depicted as the means ± SD for three goats or sheep from each group and were analyzed by one-way ANOVA (*P < 0.05, **P < 0.01, ***P < 0.001).
