FIGURE 5.
(A) SET domain bifurcated histone lysine methyltransferase1 (SETDB1), a transcription factor identified using the GSCALite website, influences the relationship between miR-409-3p and SOD1 in NSCLC. (B) Relationship among SOD1, miR-409-3p, and SETDB1. (C) The regulatory networks of miR-409-3p and SETDB1 both include SOD1. ((D-a) Spearman correlation coefficient analyses of methylation and gene expression in ADC and SCC. (D-b) Differences in methylation between tumors and normal tissue. (E) Proposed feedforward loop by which SOD1 exert its functions in NSCLC cells.