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. 2020 Apr 23;7:54. doi: 10.3389/fmolb.2020.00054

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Copyright © 2020 Ramirez, Kohar and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Constructing context-specific gene regulatory networks. (A) Representative networks yielding high accuracy scores for various conditions. Activating interactions denoted as blue arrows and inhibitory interactions as red round-tipped arrows. (B) Accuracy dependence on various network properties for all conditions. (B1–B3) Points showing accuracy (measured as fraction of models that can be classified as E or M) of models for various (B1) number of TFs in the network, (B2) fraction of TFs assigned as E or M using experimental data, (B3) number of interactions in the network. (B4–B6) Box plots showing accuracy of networks for various (B4) mutual information cutoffs for inhibitory interactions, (B5) mutual information cutoffs for excitatory interactions, (B6) different experimental conditions.