Table 1.
Baseline patient characteristics.
| Maintenance therapy regimen | ||||
|---|---|---|---|---|
| Variable | Cetuximab | Bevacizumab | All | |
| n = 79 (55.2%) | n = 64 (44.8%) | P-value | n = 143 (100%) | |
| Gender | 0.24 | |||
| Female | 27 (34.2%) | 28 (43.8%) | 55(38.5%) | |
| Male | 52 (65.8%) | 36 (56.3%) | 88 (61.5%) | |
| Age at maintenance, median (range) | 62.0 (21.0–90.0) | 61.0 (24.0–76.0) | 0.70 | 62.0 (21.0–90.0) |
| Smoking | 0.21 | |||
| Yes | 34 (43.0%) | 21 (32.8%) | 55 (38.5%) | |
| No | 45 (57.0%) | 43 (67.2%) | 88 (61.5%) | |
| Primary tumor site | 0.01 | |||
| Right colon | 11 (13.9%) | 24 (37.5%) | 35 (24.5%) | |
| Left colon | 68 (86.1%) | 40 (62.5%) | 108 (75.5%) | |
| Number of metastatic sites at start of maintenance therapy | 0.16 | |||
| 0 | 0 (0.0%) | 2 (3.1%) | 2 (1.4%) | |
| 1 | 35 (44.3%) | 18 (28.1%) | 53 (37.1%) | |
| 2 | 28 (35.4%) | 25 (39.1%) | 53 (37.1%) | |
| ≥3 | 14 (17.7%) | 16 (25.0%) | 30 (21.0%) | |
| Unknown | 2 (2.5%) | 3 (4.7%) | 5 (3.5%) | |
| Metastatic time | 0.49 | |||
| Synchronous | 51 (64.6%) | 39 (60.9%) | 90 (62.9%) | |
| Metachronous | 26 (32.9%) | 25 (39.1%) | 51 (35.7%) | |
| Unknown | 2 (2.5%) | 0 (0.0%) | 2 (1.4%) | |
| Preoperative chemotherapy | 0.10 | |||
| Yes | 20 (25.3%) | 9 (14.1%) | 29 (20.3%) | |
| No | 59 (74.7%) | 55 (85.9%) | 114 (79.7%) | |
| Surgical resection of primary tumor | 0.16 | |||
| Yes | 59 (74.7%) | 54 (84.4%) | 113 (79.0%) | |
| No | 20 (25.3%) | 10 (15.6%) | 30 (21.0%) | |
| Surgical resection of metastatic sites | 0.83 | |||
| Yes | 26 (32.9%) | 20 (31.3%) | 46 (32.2%) | |
| No | 53 (67.1%) | 44 (68.8%) | 97 (67.8%) | |
| Simultaneous resection | 0.80 | |||
| Yes | 10 (12.7%) | 10 (15.6%) | 20 (14.0%) | |
| No | 68 (86.1%) | 54 (84.4%) | 122 (85.3%) | |
| Unknown | 1 (1.3%) | 0 (0.0%) | 1 (0.7%) | |
| Line of maintenance therapy initiated | 0.68 | |||
| 1 | 34 (43.0%) | 23 (35.9%) | 57 (39.9%) | |
| 2 | 31 (39.2%) | 29 (45.3%) | 60 (42.0%) | |
| ≥3 | 14 (17.7%) | 12 (18.8%) | 26 (18.1%) | |
simultaneous resection refers to whether metastases and primary tumor site are simultaneously resected.