Table 4.

Multivariate analyses for PFS and duration of maintenance therapy in Cet group.

	PFS		Duration of maintenance therapy
Factors	95% CI	P-value	95% CI	P-value
Resection of metastatic sites
No	1.00 (reference)		–
Yes	0.48 (0.26–0.89)	0.02	–	–
Number of metastatic sites at start of maintenance therapy
1	1.00 (reference)		–
2	2.19 (1.19–4.03)	0.01	–	–
≥3	3.24 (1.48–7.09)	0.003	–	–
Multivariate analyses for PFS and duration of maintenance therapy in Bev group
Resection of primary tumor
No	1.00 (reference)		1.00 (reference)
Yes	0.14 (0.05–0.42)	<0.0001	0.08 (0.03–0.22)	<0.0001
Metastatic time
Synchronous	1.00 (reference)		–
Metachronous	2.23 (1.04–4.79)	0.04	–	–
Line of maintenance therapy initiated
1	–	–	1.00 (reference)
2	–	–	1.63 (0.74–3.58)	0.22
≥3	–	–	3.59 (1.35–9.54)	0.01

PFS, progression-free survival; CI, confidence intervals; chemo, chemotherapy.