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. 2020 Apr 23;13:60. doi: 10.3389/fnmol.2020.00060

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Copyright © 2020 Previtali and Zambon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bundle of unsorted axons in Lama2 mutants. (A) Normal Remak fiber, formed by a non-myelin forming Schwann cell (nmfSC) with unmyelinated axons (Ax); axons are smaller than 1 μm and are well separated and ensheathed by a single non-myelin forming Schwann cell. (B–D) Bundle of unsorted, non-ensheathed, and tightly packed axons of different caliber (some are larger than 1 μm, as Ax in figure B and C), are similarly present in Lama2^dy2J/dy2J (B), Lama2^dyW/dyW (C) and Lama2^dy3K/dy3K (D) mice. Bar = 1 μm in (A), 2 μm in (B,C), 1 μm in (D).