Table 3.
Sensitivity, false positive rate, specificity and false negative rates for each of the analytical platforms employed and 95% CI.
| R2Y | Q2Y | Sensitivity | False negative rate | Specificity | False positive rate | Threshold | AUC | |
|---|---|---|---|---|---|---|---|---|
| TB disease Vs Other diseases | ||||||||
|
1H NMR n = 93 |
0.78 | 0.30 |
0.69 (0.56, 0.73) |
0.31 (0.27, 0.44) |
0.83 (0.73, 0.93) |
0.17 (0.07, 0.27) |
1.78 | 0.78 |
|
HILIC n = 107 |
0.49 | 0.23 |
0.59 (0.49, 0.67) |
0.41 (0.33, 0.51) |
0.89 (0.75, 0.92) |
0.11 (0.08, 0.25) |
3.69 | 0.76 |
|
Lipidomics ESI− n = 112 |
0.47 | 0.27 |
0.58 (0.53, 0.64) |
0.42 (0.36, 0.47) |
0.89 (0.80, 0.96) |
0.11 (0.04, 0.20) |
3.28 | 0.78 |
|
Lipidomics ESI+ n = 112 |
0.48 | 0.23 |
0.67 (0.60, 0.71) |
0.33 (0.29, 0.40) |
0.86 (0.75, 0.93) |
0.14 (0.07, 0.25) |
0.65 | 0.78 |
| Bacteriologically confirmed TB Vs Other diseases | ||||||||
|
1H NMR n = 65 |
0.92 | 0.29 |
0.82 (0.59, 0.88) |
0.18 (0.12, 0.41) |
0.77 (0.59, 0.94) |
0.23 (0.06, 0.41) |
−0.90 | 0.81 |
|
HILIC n = 77 |
0.63 | 0.21 |
0.76 (0.52, 0.81) |
0.24 (0.19, 0.48) |
0.68 (0.57, 0.86) |
0.32 (0.14, 0.43) |
−1.12 | 0.77 |
|
Lipidomics ESI− n = 79 |
0.66 | 0.14 |
0.68 (0.55, 0.77) |
0.32 (0.23, 0.45) |
0.79 (0.64, 0.95) |
0.21 (0.05, 0.36) |
−1.65 | 0.74 |
|
Lipidomics ESI+ n = 79 |
0.68 | 0.17 |
0.73 (0.59, 0.82) |
0.27 (0.18, 0.41) |
0.77 (0.59, 0.91) |
0.23 (0.09, 0.41) |
−1.47 | 0.78 |