Table 2.

Mean ratios of xenograft mass after treatment with vehicle, HI or IX10.

Comparison	Mean ratio	95% confidence interval	P-value
300 nmol/kg 1X daily*
HI vs. vehicle	2.7	[2.2; 3.4]	<0.0001
IX10 vs. vehicle	7.3	[6.0; 9.0]	<0.0001
IX10 vs. HI	2.7	[2.2; 3.3]	<0.0001
300 nmol/kg 2X daily
L6hIR xenografts†
HI vs. vehicle	4.9	[3.0; 8.1]	<0.0001
IX10 vs. vehicle	21.2	[12.8; 35.0]	<0.0001
IX10 vs. HI	4.3	[2.7; 6.8]	<0.0001
L6 xenografts‡
HI vs. vehicle	1.5	[1.1; 2.1]	0.0121
IX10 vs. vehicle	1.9	[1.4; 2.6]	<0.0001
IX10 vs. HI	1.3	[0.9; 1.7]	0.1924
600 nmol/kg 1X daily§
HI vs. vehicle	2.8	[2.0; 3.8]	<0.0001
IX10 vs. vehicle	6.1	[4.4; 8.3]	<0.0001
IX10 vs. HI	2.2	[1.6; 3.0]	<0.0001

*Combined analysis of groups from experiment B, C, D, F and G. Experiments are described in Table 4.

^†Analysis of experiment C.

^‡Analysis of experiment E.

^§Analysis of experiment D.