Table 4.

Animal experiments included in this study.

Experiment	Purpose	Treatments included	Results described in
A	Acute IR and IGF-1R activation in L6hIR xenografts after a single acute treatment	Vehicle HI, 300 nmol/kg IX10, 300 nmol/kg Analogue A, 300 nmol/kg Analogue B, 300 nmol/kg	Fig. 1, Supplementary Table S5
B	Explore effect of treatment for 24 days on L6hIR xenograft growth	Vehicle HI, 300 nmol/kg 1X daily IX10, 300 nmol/kg 1X daily	Fig. 2, Table 2, Supplementary Table S5
C	Explore effect of treatment once daily (24 days) vs twice daily (21 days) on L6hIR xenograft growth	Vehicle HI, 300 nmol/kg 1X or 2X daily IX10, 300 nmol/kg 1X or 2X daily	Figs. 2, 3, Table 2, Supplementary Tables S4, S5
D	Explore effect of treatment with 300 vs 600 nmol/kg 1X daily for 24 days on xenograft growth	Vehicle HI, 300 nmol/kg or 600 nmol/kg 1X daily IX10, 300 nmol/kg or 600 nmol/kg 1X daily	Figs. 2, 3, Table 2, Supplementary Tables S4, S5
E	Explore effect of treatment with HI or IX10 twice daily for 24 days on L6 xenograft growth	Vehicle HI, 300 nmol/kg 2X daily IX10, 300 nmol/kg 2X daily	Fig. 2, Table 2, Supplementary Table S5
F	Explore effect of treatment once daily for 24 days with analogue A or B vs HI and IX10 on xenograft growth	Vehicle HI, 300 nmol/kg 1X daily IX10, 300 nmol/kg 1X daily Analogue A, 300 nmol/kg 1X daily Analogue B, 300 nmol/kg 1X daily	Fig. 4, Tables 2, 3, Supplementary Tables S4, S5
G	Explore effect of experimental treatments on L6hIR xenograft growth, treatment with HI and IX10 once daily for 24 days included as reference	Vehicle HI, 300 nmol/kg 1X daily IX10, 300 nmol/kg 1X daily	Table 2, Supplementary Tables S4, S5
H	Explore s.c. PK of 300 nmol/kg of HI and IX10	HI and IX10, 300 nmol/kg	Supplementary Tables S3, S5
I	Explore s.c. PK of 600 nmol/kg of HI and IX10	HI and IX10, 600 nmol/kg	Supplementary Tables S3, S5