Table 5:
Association between Ciclosporin Drug-Associated Complications and Ciclosporin levels
| Ciclosporin Level (ng/mL) | Infection (n,%) n = 10 (12.3%) |
Tremor (n,%) n = 4 (5%) |
Headache (n,%) n = 10 (12.3%) |
Hyperkalemia (n,%) n = 3 (4%) |
Acute Kidney Injury (Creatinine increase >30%) (n,%) n = 25 (31%) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No (n) | Yes (n) | Pvalue | No (n) | Yes (n) | Pvalue | No (n) | Yes (n) | Pvalue | No (n) | Yes (n) | Pvalue | No (n) | Yes (n) | P-value | ||
| 1st Quartile | First (<177) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| Mean (<237) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | |
| Peak (<347) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | |
| 2nd Quartile | First (177–263) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Mean (237–277) | 51 | 5 | 0.02* | 58 | 3 | 0.98 | 54 | 7 | 0.68 | 57 | 2 | 0.75 | 40 | 17 | 0.75 | |
| Peak (347–418) | 50 | 7 | 0.35 | 59 | 3 | 0.94 | 53 | 9 | 0.28 | 57 | 3 | 0.32 | 40 | 18 | 0.38 | |
| 3rd Quartile | First (264–330) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Mean (278–354) | 34 | 4 | 0.33 | 38 | 3 | 0.32 | 35 | 6 | 0.53 | 39 | 1 | 0.54 | 28 | 10 | 0.17 | |
| Peak (419–490) | 33 | 5 | 0.74 | 39 | 2 | 0.98 | 35 | 6 | 0.53 | 38 | 2 | 0.57 | 27 | 11 | 0.38 | |
| 4td Quartile | First (>331) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Mean (>355) | 15 | 3 | 0.76 | 20 | 0 | 0.24 | 19 | 1 | 0.25 | 19 | 0 | 0.32 | 14 | 4 | 0.24 | |
| Peak (>490) | 14 | 3 | 0.67 | 20 | 0 | 0.24 | 17 | 3 | 0.68 | 19 | 0 | 0.32 | 11 | 6 | 0.88 | |