Table 4.
Joint tertile levels of urinary 8-epi-prostagla ndin F2α with urinary biomarkers of cigarette smoke exposure in relation to risk of lung cancer among current smokers, The Shanghai Cohort Study 1986–2013
| Biomarkers of cigarette smoke exposure | Levels in tertile | Urinary 8-epi-prostaglandin F2α in tertile | |||||
|---|---|---|---|---|---|---|---|
| First tertile | Second tertile | Third tertile | |||||
| Ca/Coa | OR (95% CI)b | Ca/Coa | OR (95% CI)b | Ca/Coa | OR (95% CI)b | ||
| Total cotinine | First tertile | 15/75 | 1.00 (ref) | 13/43 | 1.15 (0.43, 3.03) | 14/28 | 1.95 (0.75, 5.08) |
| Second tertile | 32/37 | 3.70 (1.65, 8.28) | 37/61 | 1.77 (1.65, 8.28) | 52/45 | 3.32 (1.56, 7.04) | |
| Third tertile | 42/29 | 2.93 (1.33, 6.42) | 71/47 | 3.55 (1.68, 7.51) | 160/71 | 5.33 (2.64, 7.51) | |
| Total NNAL | First tertile | 21/60 | 1.00 (ref) | 17/51 | 0.78 (0.35, 1.76) | 21/35 | 1.24 (0.53, 2.89) |
| Second tertile | 37/52 | 1.52 (0.72, 3.21) | 47/52 | 1.37 (0.65, 2.91) | 64/44 | 2.10 (1.05, 4.19) | |
| Third tertile | 31/29 | 1.95 (0.84, 4.53) | 57/47 | 2.03 (0.96, 4.28) | 141/65 | 3.84 (1.93, 7.65) | |
| PheT | First tertile | 29/57 | 1.00 (ref) | 28/59 | 0.67 (0.30, 1.46) | 48/28 | 2.61 (1.19, 5.75) |
| Second tertile | 26/45 | 1.30 (0.61, 2.79) | 43/50 | 1.59 (0.77, 3.28) | 67/49 | 2.16 (1.04, 4.49) | |
| Third tertile | 34/39 | 1.67 (0.72, 3.90) | 50/42 | 2.05 (0.93, 4.53) | 111/67 | 2.90 (1.42, 5.92) | |
aCa/Co: number of case and control.
bOdds ratios (95% confidence intervals) were derived from conditional logistic regression models with adjustment for level of education, body mass index (kg/m2), number of cigarettes per day and years of smoking.