Table 5.
Urinary levels of 8-epi-prostaglandin F2α (8-epiPGF2α) in relation to lung cancer risk by years between biospecimen collection and cancer diagnosis among ever smokers, The Shanghai Cohort Study 1986–2013
| 8-epiPGF2α | Controls | <5 years | 5–<10 years | 10–<15 years | ≥15 years | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | OR (95% CI)a | Cases | OR (95% CI)a | Cases | OR (95% CI)a | Cases | OR (95% CI)a | ||
| First quartile | 121 | 15 | 1.00 | 17 | 1.00 | 15 | 1.00 | 23 | 1.00 |
| Second quartile | 124 | 27 | 1.59 (0.77, 3.25) | 29 | 1.82 (0.90, 3.68) | 27 | 1.37 (0.67, 2.77) | 24 | 1.04 (0.54, 2.00) |
| Third quartile | 126 | 23 | 1.30 (0.62, 2.72) | 31 | 1.58 (0.79, 3.18) | 27 | 1.27 (0.62, 2.58) | 29 | 1.11 (0.58, 2.10) |
| Fourth quartile | 123 | 35 | 1.96 (0.97, 3.98) | 58 | 2.70 (1.39, 5.24) | 57 | 2.73 (1.40, 5.33) | 57 | 1.88 (1.04, 3.40) |
| P for trend | 0.109 | 0.006 | 0.002 | 0.024 | |||||
aOdds ratios (95% confidence intervals) were derived from unconditional logistic regression models with adjustment for matching factors (age, years of biospecimen collection, neighborhood of residence at baseline), level of education, body mass index (kg/m2), smoking status, number of cigarettes/day and years of smoking.