Table 4.

Recommendations for Whom and When to Treat Among Hepatitis C Virus-infected Children

Recommendation	Rating
If direct-acting antiviral regimens are available for a child’s age group, treatment is recommended for all hepatitis C virus-infected children aged >3 years as they will benefit from antiviral therapy, independent of disease severity.	I, B
Treatment of children aged 3 to 12 years with chronic hepatitis C should be deferred until interferon-free regimens are available.	II, C
The presence of extrahepatic manifestations, such as cryoglobulinemia, rashes, and glomerulonephritis, as well as advanced fibrosis should lead to early antiviral therapy to minimize future morbidity and mortality.	I, C