Table 1.
Summary of inhibition of SecA-only liposomes activities by SecA inhibitors. SecA of E. coli (EcSecA), P. aeruginosa (PaSecA), S. aureus (SaSecA1) and B. anthracis (BaSecA1) were tested. A. IC50 for ion channel activity of SecA-liposome determined in the oocytes; B. ProOmpA translocation into SecA-liposomes (From Hsieh et al.2013; Jin et al.2016. * indicates unpublished data; ND, not determined).
| A. Inhibition on liposome ion-channel activity, IC50 (μM) | ||||
|---|---|---|---|---|
| SecA protein | RB | SCA-50 | SCA-15 | SCA-107 |
| M r: 1017 | M r: 298 | M r: 436 | M r: 472 | |
| EcSecA | 0.4 | 2.3 | *4.2 | 1.6 |
| PaSecA | 0.3 | 3.0 | *3.2 | 1.3 |
| SaSecA1 | 0.4 | 1.0 | *2.3 | 0.6 |
| BaSecA1 | 0.3 | *1.0 | *2.8 | 0.7 |
| B. Inhibition on liposomes translocation activity, IC50 (μM) | ||||
| EcSecA | PaSecA | SaSecA1 | BaSecA1 | |
| SCA-107 | 3.5 | 3.0 | *2.0 | *2.8 |
| Rose Bengal | 1.0 | 1.0 | *1.0 | ND |