Table 2.
MIC of SecA inhibitors to various bacterial strains, including some Gram-positive and Gram-negative MRSA and MDR pathogens. *With (+ ) or without (-) PMBN (Polymxin B nanopeptide) which alone had no inhibition on growth ND, not determined (From Jin et al., 2015, 2016;).
| Strains, MIC (μM) | PMBN* | RB | SCA-50 | SCA-15 | SCA-107 | Vancomycin |
|---|---|---|---|---|---|---|
| Mr: 1017 | Mr: 298 | Mr: 436 | Mr: 472 | Mr: 1446 | ||
| Gram-positive bacteria | ||||||
| S. aureus Mu50 | - | 50.0 | 12.5 | *5.0 | 1.6 | 5.5 |
| S. aureus Newman | - | 50.0 | 12.5 | ND | 1.6 | ND |
| B. anthracis Sterling | - | ND | *6.3 | 6.3 | 3.1 | ND |
| Gram-negative bacteria | ||||||
| E. coli NR698 | - | 4.4 | 15.8 | 12.5 | 5.2 | ND |
| E. coli MC4100 | - | >1250 | >1250 | >1250 | >1250 | >150 |
| E. coli MC4100 | + | 15.6 | 3.0 | 15.6 | 1.5 | 21.6 |
| P. aeruginosa T15464 | + | 0.4 | 6.3 | ND | 0.4 | 21.6 |
| A. baumannii ATCC9955 | + | 79.2 | 25.0 | ND | 2.1 | 172.5 |
| S. flexneri ATCC12022 | + | 7.4 | 5.8 | 25.0 | 4.7 | 43.1 |