Table 3A.

Changes of sensitivity to SecA inhibitors by SecYEG for ion channel activuity in the oocytes. SecA-liposomes reconstituted with equal amount of SecYEG as in the MC4100 membranes (Memb). The SecYEG in MC4100 or PrlA4* membranes was removed by cholate (Watanabe, Nicchitta and Blobel 1990) to yield reconstituted membrane (RE-4100 Memb); and then similarly reconstituted with SecYEG-DFC (Re-MC4100 + SecYEGDFC) or RE-PrlA4 Memb. (Hsieh et al.2011, 2017a).

A. Changes of ion channel sensitivity to SecA inhibitors by SecYEG
Channel activity IC50 (μM)	SecA-liposomes	SecA-lipo + YEGDFC	MC4100 Memb	RE-MC4100 Memb	RE-MC4100 + YEGDFC	PrlA4 Memb	RE- PrlA4 Memb
Rose Bengal	0.4	3.8	4.7	0.4	4.4	73	0.6
SCA-107	1.1	3.3	2.9	0.8	2.1	>90	2.5