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. 2020 Apr 13;130(5):2496–2508. doi: 10.1172/JCI131241

Figure 7. STAT5 regulates the neonatal fate of intestinal T-bet+ γδT17 cells.

Figure 7

Flow cytometric analysis of colonic γδ T cells in RORγtCRE-STAT5F/F (Cre+) and littermate control mice (Cre−) during neonatal ontogeny. Day of birth is counted as day 1 (d1). In graphs, each symbol represents a mouse, and lines represent the median. *P < 0.05, ***P < 0.001, ****P < 0.0001 using Mann-Whitney test. (A) Expression of RORγt and T-bet within the γδ T cell compartment of cLP at the indicated days after birth. Numbers indicate percentage of RORγt and T-bet expression. (B) Frequency of cLP RORγt+T-bet+ γδ T cells at the indicated days after birth. (C) Frequency of cLP RORγt+ γδ T cells (including T-bet+) at the indicated days after birth. (D) Frequency of cLP Ki67+RORγt+ γδ T cells at the indicated days after birth. (A–D) n = 2–16 mice from at least 5 different litters.