Table 4.
Influence of prior statin persistence on antihypertensive adherence trajectories following initiation of antihypertensive therapy
| Statin persist subcohort (n = 69,668) | Trajectory group (n, %) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Immediate drop-off | Rapid drop-off | Gradual drop-off | Partial drop-off | Early drop-off then rebound | Adherent | |||||||
| Persistent ≥ 180 days (n = 47,668) | 6,727 | 14.1 | 3,295 | 6.9 | 6,517 | 13.7 | 3,781 | 7.9 | 4,759 | 10.0 | 22,589 | 47.4 |
| Not persistent at least 180 days (n = 22,000) | 4,215 | 19.2 | 2,003 | 9.1 | 3,501 | 15.9 | 2,973 | 13.5 | 2,454 | 11.2 | 6,854 | 31.2 |
| Baseline prediction model + prior statin persistence | ||||||||||||
| Multivariable odds ratio (95% CI)a | 0.48 (0.46, 0.51) | 0.49 (0.46, 0.53) | 0.56 (0.54, 0.59) | 0.40 (0.38, 0.42) | 0.60 (0.57, 0.64) | Referent | ||||||
AUC-statistic adjusted for all baseline covariates and prior statin persistence: 0.531. Abbreviation: AUC, Area under the receiving operating characteristic curves; CI, confidence interval; OR, odds ratio.
aOdds ratio comparing prior statin persistence and the odds of belonging to the adherent group. Adjusted for all baseline covariates. ORs <1 are predictive of being more adherent. Sixty-eight observations were removed due to missing beneficiary race/ethnicity.