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. 2020 Apr 6;130(5):2391–2407. doi: 10.1172/JCI127502

Figure 4. Hepatic global DNA methylation analyses by ERRBS.

Figure 4

(A) Scatter plot representation of global promoter DNA methylation analyses by enhanced reduced representation bisulfite sequencing ERRBS (n = 4, 4 litters per group). (B) Genomic features of hepatic DNA methylation. All CpGs, all detected cytosines; DM CpGs, differently methylated cytosines; Hyper. CpGs, hypermethylated cytosines; Hypo. CpGs, hypomethylated cytosines. (C) Selected pathways of genes with increased promoter DNA methylation (genes selected for methylation > 0% and FDR < 0.05). (D) Selected pathways of genes with decreased promoter DNA methylation (genes selected for methylation < 0% a/nd FDR < 0.05). (E) DNA methylation in selected covered CpGs spanning the Gdf15 promoter. (F) DNA methylation in selected covered CpGs spanning the Nrep promoter. **FDR < 0.01; ***FDR < 0.001.