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. 2020 Mar 23;130(5):2220–2236. doi: 10.1172/JCI131800

Figure 1. Qki regulates myelin homeostasis independently of oligodendrocyte death.

Figure 1

(A) Representative electron micrographs and quantification of the optic nerves of Qk-iCKO mice and controls (Ctrl) 1, 2, and 5 weeks post tamoxifen injection (wpi). n = 4 mice/group. Scale bars: 500 nm. (B and C) Quantification of dead cells by TUNEL assay and immunofluorescent staining of cleaved caspase 3 (Clv–casp-3) in the corpus callosum of the experimental mice in A (n = 4 mice/group). (D and E) Representative images and quantification of immunofluorescent staining of GSTpi-Qki (D) and ASPA-Qki (E) in the corpus callosum of the experimental mice in A (n = 4 mice/group). Scale bars: 50 μm. Data are mean ± SD. *P < 0.05; ****P < 0.0001 by 2-way ANOVA with Holm-Sidak multiple-comparisons test. NS, not significant.