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List of significant biological barriers to ingested RNAs in humans.
|
Biological Barriers | ||
| Gastrointestinal | Systemic | Cellular |
| Saliva | Vascular endothelium | Cellular and nuclear membrane barriers |
| Stomach acids/Digestive enzymes | Serum nucleases | Endosomes and lysosomes |
| Pancreatic nucleases | Renal filtration and elimination | Sufficient sequence identity |
| GI epithelium and tight junctions | Tissue epithelium | Gene target accessibility |
