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. 2020 Apr 1;10(4):1182–1193.

Figure 3.

Figure 3

ARF6 regulates the sensitivity to RSL3 via ACSL4. A. Western blotting analyzed ACSL4, GPx4, FSP1, SCD1 expression in PANC-1 and MIA PaCa-2 cells that silenced ARF6 or not. B. qRT-PCR analyzed the change of ACSL4 mRNA in PANC-1 and MIA PaCa-2 cells that silenced ARF6 or not. C and D. Dose-dependent toxicity of RSL3 was analyzed in ARF6 silenced PANC-1 and MIA PaCa-2 that pretreated with ROSI or not. E and F. MDA level was detected in AR6 silenced PANC-1 and MIA PaCa-2 cells that pretreated with ROSI or not. G. qRT-PCR analyzed the change of ACSL4 mRNA in PANC-1 and MIA PaCa-2 cells that silenced ARF6 or not. H. Cell viability was analyzed in ARF6 silenced PANC-1 and MIA PaCa-2 that pretreated with OA (80 mmol/L) or not.