Table 1.
The association of NKX2-1 and TNFSF10 mRNA expression levels with tumor response in patients with lung adenocarcinoma who received cisplatin-based chemotherapy
| Variables | Patients No. | Tumor response | P value | |
|---|---|---|---|---|
|
| ||||
| Favorable | Unfavorable | |||
| p53 status | ||||
| p53-WT | 78 | 28 (36) | 50 (64) | 0.217 |
| p53-MT | 19 | 4 (21) | 15 (79) | |
| TNFSF10 | ||||
| Low | 48 | 10 (21) | 38 (79) | 0.012 |
| High | 49 | 22 (45) | 27 (55) | |
| NKX2-1 | ||||
| Low | 48 | 12 (25) | 36 (75) | 0.131 |
| High | 49 | 20 (41) | 29 (59) | |
| p53-WT | ||||
| TNFSF10 | ||||
| Low | 36 | 12 (33) | 24 (67) | |
| High | 42 | 32 (76) | 10 (24) | < 0.0001 |
| NKX2-1 | ||||
| Low | 42 | 8 (17) | 34 (83) | 0.001 |
| High | 36 | 20 (56) | 16 (44) | |
| p53-MT | ||||
| TNFSF10 | ||||
| Low | 12 | 2 (17) | 10 (73) | |
| High | 7 | 3 (43) | 4 (54) | 0.103 |
| NKX2-1 | ||||
| Low | 6 | 4 (66) | 2 (34) | 0.004 |
| High | 13 | 0 (0) | 13 (100) | |
The median value of NKX2-1 and TNFSF10 mRNA expression levels were used to as an cutoff point to divide patients’ tumors into “low” and “high” subgroups. P values were obtained from the statistical analysis by Chi-square test.