Figure 3.

Voluntary Motor Behavior and Muscular Strength Are Not Affected in Aged Gdnf^wt/hyper Mice

(A) Number of crossed lines during beam walking test. Welch’s t test: p = 0.319. (B) Latency to fall from the beam in the beam walking test. Mann-Whitney U test: p = 0.721. (C) Latency to turn on each rod in the multiple static rods test. Multiple t test: rod 1 (p = 0.428), rod 2 (p = 0.652), rod 3 (p = 0.859), rod 4 (p = 0.833), and rod 5 (p = 0.304). (D) Time to reach the platform (escape and travel to the supporting beam) on each rod in the multiple static rods test. Multiple t test: rod 1 (p = 0.517), rod 2 (p = 0.26), rod 3 (p = 0.374), rod 4 (p = 0.526), and rod 5 (p = 0.404). (E) Score given in the coat hanger test. Welch’s t test: p = 0.652. (F) Latency to reach the lines in the coat hanger test. Welch’s t test: line 1 (end of horizontal part), p = 0.458; line 2 (diagonal part of the coat hanger), p = 0.823. (G) Latency to fall off in the coat hanger test. Mann-Whitney U test: p = 0.375. (H) Maximal forepaw pulling force measured in the grip strength test. Welch’s t test: p = 0.06. (A, B, and E–H) n = 25 Gdnf^wt/wt and n = 20 Gdnf^wt/hyper. (C and D) n = 18 Gdnf^wt/wt and n = 13 Gdnf^wt/hyper. Data are presented as mean ± SEM. BW, beam walking; CH, coat hanger; MSR, multiple static rod.