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A Schematic Illustration of ZFAS1/miR-548e/CXCR4 Signaling Axis in Regulating OC Cell Proliferation, Metastasis, and Cisplatin Resistance
In OC cells, ZFAS1 binds with miR-548e to enhance CXCR4 expression to promote OC cell proliferation, metastasis, and invasion, resulting in EMT and OC metastasis. Under cisplatin treatment, the ZFAS1/miR-548e/CXCR4 axis further suppresses let-7a expression and elevates BCL-XL/S expression to enhance OC cell resistance to cisplatin treatment.
