Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 7;20:621–638. doi: 10.1016/j.omtn.2020.03.013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

miR-548e Impairs OC Cell Resistance to Cisplatin by Repressing CXCR4 Expression

(A) Effects of miR-548e mimics and CXCR4 overexpression on resistance of SKOV3 and Caov3 cells to cisplatin treatments. Viabilities of cells treated with 2, 4, 6, 8, or 10 μM cisplatin were detected using the CCK-8 assay, and IC₅₀ values were calculated to evaluate drug resistance. (B) The cisplatin-induced SKOV3 and Caov3 cell apoptosis after being transfected with miR-548e mimics and CXCR4 overexpressing plasmids. Flow cytometry was used to detect cell apoptosis. NC, negative control; CXCR4, chemokine receptor 4; IC₅₀, half maximal inhibitory concentration; ∗p < 0.05 and ∗∗p < 0.01.