Table 3.

Univariate and multivariate Cox regression analysis of entire cohort

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Training set, n = 219
Age: ≥ 60/< 60	0.88 (0.45-1.73)	0.719
Gender: Male/Female	1.10 (0.59-2.03)	0.098
Stage: I-II/III-IV	2.79 (1.43-5.44)	0.002	4.10 (1.75-9.97)	0.018
Tumor: T3-T4/T1-T2	3.14 (0.97-8.21)	0.047	1.34 (0.38-4.82)	0.063
Metastasis: M0/M1	3.58 (1.87-6.86)	< 0.001	2.23 (1.06-4.73)	0.035
Node: N0/N1-N2	2.49 (1.34-4.66)	0.004	0.43 (0.09-2.06)	0.055
Risk score: High/Low	3.42 (1.84-6.40)	< 0.001	3.22 (1.62-6.39)	< 0.001
Testing set, n = 219
Age: ≥ 60/< 60	1.60 (0.77-3.33)	0.204
Gender: Male/Female	1.30 (0.73-2.32)	0.369
Stage: I-II/III-IV	3.75 (2.01-6.99)	< 0.001	3.35 (1.94-9.43)	0.006
Tumor: T3-T4/T1-T2	3.02 (0.94-9.77)	0.044	6.80 (0.89-22.13)	0.065
Metastasis: M0/M1	3.38 (1.91-6.00)	< 0.001	2.23 (1.14-4.34)	0.018
Node: N0/N1-N2	3.37 (1.86-6.12)	< 0.001	0.22 (0.05-0.99)	0.048
Risk score: High/Low	2.33 (1.31-4.15)	0.003	2.34 (1.26-4.34)	0.007

HR, hazard ratio; CI, confidential interval.