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Overview of the pathogenesis of asthma. The combined influence of genetic and environmental factors mediates Th2 and non-Th2 types of inflammation, leading to the production of various cytokines by eosinophils, neutrophils, mast cells, etc. and ultimately causing AHR, mucus hypersecretion and airway remodeling. ILC2: type 2 innate lymphoid cells; TSLP: thymic stromal lymphopoietin; IFN-γ: interferon-γ.
