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. 2020 Apr 15;12(4):1379–1396.

Figure 1.

Figure 1

Molecular biomarkers, secreted by brain tumor cells, can enter into the cerebrospinal fluid (CSF). Therefore, CSF may contain increased levels of ctDNA, miRNA, proteins and EVs. Fortunately, CSF is easily obtained through lumbar puncture or surgery. Using liquid biopsy techniques, changes on the expression of ctDNA, miRNA, proteins and EVs from brain tumor cells can be examined in the CSF.