Figure 6.

Knockdown of ARNTL2 suppressed CC invasion in vivo. A. ARNTL2 knockdown significantly inhibited CC invasion in vivo. At the indicated times, subcutaneous tumor volumes were measured with calipers (mean ± SD, n=5). B. HCT-15 cells stably infected with ARNTL2 shRNA or control shRNA were injected into the nude mice. C. Tumors were removed from mice after post-cells injection for 28 days. D. The tumors were analyzed by HE staining, and the expression of ARNTL2 and growth index Ki-67 was detected by immunohistochemistry.